Ingredients
Extra virgin olive oil, coconut oil,
Vitamin D3 (Cholecalciferol).
1 drop = 2000 IU.
Glass flask with dropper, 20 ml (400 drops).
Physiological effect
Osteoporosis, Bone demineralization,
Autoimmune diseases, Neurodegenerative diseases.
Features
In Italy, 80% of the population is deficient in vitamin D3, which begins with young people to worsen with advancing age until it affects almost the entire Italian elderly population that does not take vitamin D3 supplements. The disorders due to Vitamin D3 deficiency are: decrease in serum levels of calcium and phosphorus with consequent secondary hyperparathyroidism and increased concentration of alkaline phosphatase, alteration of mineralization processes with rickets (in children), osteomalacia (in adults), muscle weakness with bone deformation and pain. Vitamin D3 has been the subject of many studies in recent years that have shown that its deficiency is linked to several diseases from influenza to multiple sclerosis. Particular attention has been paid to pregnant women. During pregnancy and breastfeeding, vitamin D3 is essential for the maturation of the skeleton of the fetus and the newborn, without it this does not happen, consequently the need increases. The administration of boluses should be used in the presence of severe deficiency to quickly restore blood levels but the daily oral therapy of lower doses is the most constant and effective over time. In the literature all the cases of toxicity published are for doses higher than 40,000 IU per day. Since Vitamin D3 is responsible for the restoration of calcium in the bones in case of prolonged intake, calcification of soft tissue may occur. To avoid this side effect it is necessary the complementary intake of Vitamin K2 - MK7 (MENACHINONE-7).
Studies
Some in vitro experiments carried out in 2000 showed that 1.25(OH)D can stimulate the production of human catelicidin (human cathelicidin antimicrobial peptide, CAMP), a peptide with antimicrobial action, significantly reducing the incidence of acute respiratory infections. A recent meta-analysis has also found a strong correlation between vitamin D deficiency and autoimmune thyroiditis (Hashimoto and Graves). In addition, on June 8, 2007 in the journal "American Journal of Clinical Nutrition", Prof. Johan Lappe of Creighton University states that vitamin D reduces the risk of cancer with vitamin D intake (1100 IU/day). On February 21, 2011 a study was published in the journal "Anticancer Research" in which it was found that daily intake of vitamin D in dosages of 4,000-8,000 IU reduces the risk of several diseases such as type 1 diabetes mellitus by about half and that high levels of vitamin D in the blood decreases mortality from breast, colorectal and lung cancer. There is a growing belief that Vitamin D3 is a "neurosteroid hormone" that can affect cognitive decline, multiple sclerosis and even Alzheimer's disease. Finally, vitamin D supplementation (≥800 IU per day) was found to be useful in relieving the symptoms of depression, in the study the effect was comparable to that of anti-depressant drugs.